教授 清水 克悦

教員情報

教授 清水 克悦

教授 清水 克悦 SHIMIZU KATSUYOSHI

         
身分 教授(員外)
資格
  • 日本脳神経外科認定医
  • 日本脳卒中学会専門医
  • 日本神経内視鏡学会技術認定医
専門分野
  • 脳神経外科
  • 顔面けいれん、三叉神経痛
  • 良性腫瘍(髄膜腫、聴神経腫瘍、眼窩内腫瘍、下垂体腺腫)
  • 頭蓋底腫瘍
  • 脳血管障害
  • 虚血耐性
学位
  • 博士(医学) アデノシンの虚血時脳保護効果についての研究
e-mail 非公開
主な所属
  • 医学部脳神経外科学
最終学歴 慶應義塾大学医学部
担当科目
  • 脳神経外科学
研究内容
  • 虚血耐性の基礎研究
  • mitochondrial ATP sensitive potassium channel
  • 頭蓋頚移行部の臨床解剖
所属学会
  • 日本脳神経外科学会
  • 日本脳神経外科コングレス
  • 日本脳卒中学会
  • 日本神経内視鏡学会
  • 日本脳卒中の外科学会
  • 日本頭蓋底外科学会
  • 日本脳腫瘍の外科学会
受賞、表彰
著作論文
  • 1. Shimizu, K., Ogino, M., Yamaguchi, N., Mitani, S., Saito, R., Kawase, T., and Toya, S.: Propentofylline (HWA285) inhibits the release of dopamine during transient ischemia and modulates its metabolism in rat striatum. Neurosci Lett. 158: 9-12, 1993
  • 2. Shimizu, K. The neuroprotective effects of adenosine against ischemic insult in rat striatum - A study using in vivo microdialysis - . The Keio Journal of Medicine 72: 353-364, 1995
  • 3. 古旗茂、清水克悦、高宮至昭 意欲障害,知的機能障害のみならず,情緒障害にもプロペントフィリンが著効を示した脳梗塞後遺症患者の1症例 老化と疾患 vol.8 (No. 9), 60-62, 1995
  • 4. Shimizu, K., Yamada, F., Fukuda, S., and Toya, S. Spontaneous disappearance of a cerebral arteriovenous malformation. - Case report - . Neurol Med Chir 36: 26-30, 1996
  • 5. 古旗茂、清水克悦、高宮至昭 クモ膜下出血で発症したAVM症例の検討 東京都医師会雑誌 48: 1499-1500, 1996
  • 6. 古旗茂、清水克悦、高宮至昭 脳幹梗塞による手掌口症候群の一例 東京都医師会雑誌 49: 1190-1191, 1996
  • 7. 古旗茂、成高平治、高宮至昭、清水克悦、亀谷徹 プロラクチン産生腺腫と成長ホルモン産生腺腫の分類検討および、後者と糖蛋白ホルモンαサブユニットの意義 ホルモンと臨床(増)44: 106-110, 1996
  • 8. Ishikawa, M., Sekizuka, E., Shimizu, K., Yamaguchi, N., and Kawase, T. Measurement of RBC velocities in the rat pial arteries with an image-intensified high-speed video camera system. Microvascular Research 56: 166-172. 1998
  • 9. Ishikawa, M., Sekizuka, E., Sato, S., Shimizu, K., Yamaguchi, N., and Kawase, T. In vivo rat closed spinal window for spinal microcirculation: observation of pial vessels, leukocyte adhesion, and red blood cell velocity. Neurosurgery 44: 156-161, 1999
  • 10. Shimizu, K., Furuhata, S., Sasai, S., Tominaga, S., and Takamiya, Y. Intracerebral cystic meningioma - case report. Neurol Med Chir 39: 530-533, 1999
  • 11. Shimizu, K., Takamiya, Y., Furuhata, S., Naritaka, H., and Kameya, T. Cystic lesion at the foramen magnum disseminated from a pituitary adenoma - case report. Neurol Med Chir 39: 606-611, 1999
  • 12. Shimizu, K., Veltkamp, R., and Busija, D.W. Characteristics of induced spreading depression after transient focal ischemia in the rat. Brain Res 861: 316-324, 2000
  • 13. Shimizu, K., Bari, F., and Busija, D.W. Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat. Neuroreport 11: 2103-2106, 2000
  • 14. Rajapakse, N., Shimizu, K., Payne, M. and Busija, D. Isolation and characterization of intact mitochondria from neonatal rat brain. Brain Res Brain Res Protoc, 8:176-83, 2001
  • 15. 留学報告「米国留学を終えて」刀林 78: 7, 2001. 12. 17.
  • 16. Shimizu, K., Miller, AW., Erdo-s, B., Bari, F., Busija, D.W. Role of endothelium in hyperemia during cortical spreading depression (CSD) in the rat. Brain Res 928: 40-49, 2002
  • 17. Domoki F, Perciaccante JV, Shimizu K, Puskar M, Busija DW, Bari F. N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets. Am J Physiol Heart Circ Physiol 282: H1404-9, 2002
  • 18. Rajapakse N., Shimizu K., Snipes J., Lacza Z., Busija D.W.. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci Lett 327: 208-212, 2002
  • 19. Horiguchi T, Shima H, Suga S, Ogino M, Shimizu K, Toya S, Nagao M, Kawase T. Transient forebrain ischemia induces expression of serine/threonine protein phosphatase 1 mRNA in the vulnerable regions of gerbil brain. Neurosci Lett 325:115-8, 2002
  • 20. Shimizu, K., Lacza, Z., Rajapakse, N., Horiguchi, T., Snipes, J., Busija, D.W.. MitoKATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am J Physiol Heart Circ Physiol 283: H1005-1011, 2002
  • 21. Horiguchi, T., Shimizu, K., Ogino, M., Yamaguchi, N., Suga, S., Inamasu, J., Kawase, T. Neuroprotection role of adenosine under hypothermia in the rat global ischemia involves inhibition of not dopamine release but delayed postischemic hypoperfusion. Brain Res 952: 222-231, 2002
  • 22. Veltkamp R, Rajapakse N, Robins G, Puskar M, Shimizu K, Busija DW. Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels. Stroke 33: 2704-10, 2002
  • 23. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Protective effect of a new nonpeptydil mimetic of SOD, M40401 against focal cerebral ischemia in the rat. Brain Res 963: 8-14, 2003
  • 24. Horiguchi, T., Kis, B., Rajapakse N., Shimizu, K., Busija, D.W. Opening of Mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats. Stroke 34: 1015-1020, 2003
  • 25. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Neuroprotection against hypoxia-ischemia in neonatal rat by novel superoxide dismutase mimetics. Neurosci Lett 346: 41-44, 2003
  • 26. Horiguchi, T., Shimizu, K., Ogino, M., Suga, S., Inamasu, J., Kawase, T. Postischemic hypothermia inhibits the generation of hydroxyl radical following transient forebrain ischemia in rats. J Neurotrauma 20: 511-520, 2003
  • 27. 私の研究「虚血脳障害のメカニズムの解明」刀林 81: 7, 2003. 5. 9
  • 28. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T. Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection. Brain Res Rev 46: 282-294, 2004
  • 29. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res 1039: 84-89, 2005
  • 30. 清水克悦 13C-MRSによるサルの脳グルコース代謝 慶應医学 82(2): 75-77, 2005
  • 31. Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain Res. 1062: 127-33, 2005
  • 32. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 140(2):723-30, 2006
  • 33. Busija DW, Bari F, Domoki F, Horiguchi T, Shimizu K. Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog Neurobiol. 86(4): 417-33, 2008
  • 34. Shimizu K, Ochiai M. Primary diffuse B-cell lymphoma presenting as a subdural tumor associated with calcified chronic subdural hematoma. Case report and review of the literature. Chirurgia 25(1): 77-81, 2012
  • 35. Fukunaga A, Shimizu K, Ochiai M, Yazaki T. Interhemispheric arachnoid cyst presenting with dementia treated by direct surgery: a case report and review of the literature. Chirurgia 26(3): 253-258, 2013
  • 36. Fukunaga A, Shimzu K, Yazaki T, Ochiai M. A recommendation of the basis of long-term follow-up results of our microvascular decompression operation for hemifacial spasm. Acta Neurochir 155: 1693-1697, 2013
  • 37. 清水克悦 三叉神経痛・顔面けいれんの外科治療 Dental Medical Research 33(1) : 140, 2013.03
  • 38. Kobayashi Y, Sasaki A, Tsuji M, Udaka Y, Oyamada H, Iwai S, Somei M, Kizaki J, Kondo Y, Shimizu K, Mizutani T. Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression. Showa University Journal of Medical Science 25(4): 255-262, 2013
  • 39. Fukunaga A, Yazaki T, Shimizu K, Ochiai M. A case of pituitary metastasis in a patient with male breast cancer developing anterior lobe dysfunction successfully treated by using hormone replacement therapy. No Shinkei Geka 42(7): 629-633, 2014 Japanese
  • 40. 清水克悦 片側顔面痙攣・三叉神経痛の根治術 昭和学士会雑誌 74(5): 513-519, 2014
  • 41. 谷岡大輔, 清水克悦, 水谷徹 皮弁トラブルを低減するための閉頭法の工夫 -チタンプレートを用いない閉頭法- 日本整容脳神経外科記録集 6: 11-14, 2014
  • 42. 奥村浩隆、水谷 徹、杉山達也、九社前実香、藤島裕丈、中條敬人、藪崎 肇、松村 優、入江 亮、川内雄太、松本政輝、中山禎理、鷲見賢司 谷岡大輔、和田 晃、清水克悦 内頚動脈海綿静脈洞部巨大動脈瘤塞栓術後に脳膿瘍をきたした1例 Journal of Neuroendovascular Therapy 8(2): 89-94, 2014
  • 43. 杉山達也、水谷 徹、清水克悦、和田 晃、谷岡大輔、奥村浩隆 前方循環の脳動脈瘤に対する安全・確実な開頭クリッピング術の手術戦略 ―中大脳動脈瘤に対する開頭クリッピング術:若手脳神経外科医の教育を中心に― 昭和学士会雑誌 74(5): 497-503, 2014
  • 44. Shimizu K, Matsumoto M, Wada A, Sugiyama T, Tanioka D, Okumura H, Fujishima H, Nakajo T, Nakayama S, Yabuzaki H, Mizutani T. Supine No-Retractor Method in Microvascular Decompression for Hemifacial Spasm: Results of 100 Consecutive Operations. J Neurol Surg B Skull Base 76(3): 202-207, 2015
  • 45. Shimizu K, Matsumoto M, Wada A, Mizutani T. Lateral basal approach with a supine, no-retractor method for microvascular decompression for hemifacial spasm. Acta Neurochir 157(5): 803-806, 2015
  • 46. Shimizu K, Wada A, Kushamae Mika, Irie R, Kawauchi U, Kato Y, Iizuka K, ubo M, Sakamoto Y, Ezure H, Otsuka N, Mizutani T. Lateral basal space and interlaminar fatty compartment of the deep cervical fascia in the posterolateral craniocervical junction - An anatomical basis for the surgery in the lateral skull base. Int J Neurol Neurother 3(1): 038 ISSN 2378-3001, 2016
  • 47. 谷岡大輔、飯塚一樹、久保美奈子、松村 優、入江 亮、川内雄太、九社 前実香、松本政輝、藪崎 肇、清水克悦、水谷 徹、比野平恭之 神経内視鏡下経鼻的頭蓋底手術 Video Journal of Japan Neurosurgery 22(4), 88 2015
  • 48. Sugiyama T, Mizutani T, Sumi K, Matsumoto M, Yabuzaki H, Kushamae M, Irie R, Kawauchi Y, Sakamoto Y, Shimizu K, Kubo M., Kato Y, Iizuka K. Trapping of Vertebral Aneurysms Using Mid-lateral Suboccipital Approach, with Emphasis on Securing the Distal End. Surgery for Cerebral Stroke 44(6):461-468, January 2016
  • 49. Matsumoto M, Mizutani T, Sumi K, Shimizu K. Three-dimentional fusion imaging without contrast medium for carotid endarterectomy. J Neurol Surg A Cent Eur Neurosurg. 2018 Jan;79(1): 73-76. doi: 10. 1055/s-0037-1607226. Epub 2017 Nov 1
  • 50. Arai S, Shimizu K, Yamochi T, Mizutani T, Okumura H, Nakajo T, Matsumoto M. Preoperative Embolization of Meningiomas: Differences in Surgical Operability and Histopathologic Changes Between Embosphere and N-butyl 2-cyanoacrylate.World Neurosurg. 111 113-119, 2018
  • 51. Sato Y, Mizutani T, Shimizu K, Freund HJ, Samii M. Retrosigmoid intradural suprameatal-inframeatal approach for complete surgical removal of a giant recurrent vestibular schwannoma with severe petrous bone involvement: technical case report. World Neurosurg. 110: 93-98, 2018
  • 52. Imaizumi Y, Mizutani T, Shimizu K, Sato Y, Taguchi J. Detection rates and sites of unruptured intracranial aneurysms according to sex and age: an analysis of MR angiography–based brain examinations of 4070 healthy Japanese adults. J Neurosug. 130(2) 573-578, 2018
  • 53. 清水克悦 きょうのセカンドオピニオン Q聴神経腫瘍の治療は 毎日新聞2018/7/1
  • 54. 清水克悦 Health care ようこそ、「ミセス外来」へ 顔面痙攣 雑誌ミセス 9月号No 765, 196-197
  • 55. Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M、Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki H, Sakamoto H, Nishikawa R, Ichimura K. Japan Pediatric Molecular Neuro-Oncology Group (JPMNG). Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. Acta Neuropathol Commun. 2018 Dec 4;6(1):134
その他
(メディア出演等)
  • 2010年 FNNスーパーニュース
  • 2011年 TBSテレビ「ひるおび!」で紹介 片側顔面けいれん
  • 2012年 「たけしの健康エンターテインメント! みんなの家庭の医学」 出演 片側顔面けいれん
  • 2013年~ドクターズガイドに掲載
  • 2017年 メディカルノートに紹介